Microdialysis--a novel technique for clinical investigations

Microdialysis is a novel, non-traumatic technique which, when properly performed, allows continuous direct measurements of substances in the interstitial space of a tissue or organ. It also makes it possible to obtain protein-free fluid for analyses, while contaminating bacteria or viruses are excluded. The measurements provide us with an insight into metabolic and pharmacological events at the cellular level in a target organ. Apart from its usefulness for experimental work, it is likely to become an important tool for defined areas in clinical practice.