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Updated: May 29, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
Fertility, infertility and thrombophilia
Amir Kuperman1, Pierpaolo Di Micco, Benjamin Brenner
1The Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. amir.kuperman@naharia.health.gov.il
Abstract:
Hypercoagulation has been reported in some studies to be associated with reproductive failures, such as unexplained infertility, IVF implantation failure and recurrent fetal losses. Many pregnancy-related disorders have been interpreted as consequences of impaired microvascular function and might be viewed as a mild form of venous thromboembolic disease. In the absence of clinical guidelines, there is a need for an evidence base regarding thrombophilic screening and antithrombotic therapy in cases of reproductive failure. This article will focus on the controversial effect of congenital and acquired thrombophilia on human fertility, and will review the English literature for relevant studies identified by searching PubMed(®) results between January 1966-November 2010 using the key words: 'thrombophilia', 'fertility' and 'infertility'.
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