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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

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Published on: July 11, 2025

Challenges in antimalarial drug discovery.

Jeremy N Burrows¹, Didier Leroy, Julie Lotharius

¹Medicines for Malaria Venture, Route de Pré-Bois 20, PO Box 1826, 1215 Geneva 15, Switzerland. burrowsj@mmv.org

Future Medicinal Chemistry

|September 2, 2011

Summary

This summary is machine-generated.

Malaria drug discovery is accelerating to combat the devastating global disease. New research focuses on developing next-generation antimalarials targeting Plasmodium falciparum and Plasmodium vivax.

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Area of Science:

Infectious Diseases
Parasitology
Drug Discovery

Background:

Malaria affects 225 million people annually, causing over 780,000 deaths, primarily in children under 5.
The World Health Organization (WHO) supports a global call for malaria eradication.
Increased investment is driving antimalarial drug discovery projects.

Purpose of the Study:

To summarize current strategies in antimalarial drug discovery.
To outline disease-specific considerations for planning antimalarial research and development.

Main Methods:

Review of current top-level thinking in antimalarial drug discovery.
Analysis of project planning considerations for malaria eradication.

Main Results:

Focus on generating novel molecules for treatment and transmission-blocking.
Targeting both endo- and exo-erythrocytic stages of Plasmodium falciparum and Plasmodium vivax.

Conclusions:

Strategic planning is crucial for effective antimalarial drug development.
Next-generation antimalarials are essential to combat malaria and achieve eradication goals.