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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: May 29, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

Serglycin in human cancers.

Xin-Jian Li1, Chao-Nan Qian

  • 1State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China. qianchn@ sysucc.org.cn

Chinese Journal of Cancer
|September 2, 2011
PubMed
Summary

Serglycin, a proteoglycan, promotes cancer metastasis by binding to CD44. Its role in metastasis is linked to glycosylation, highlighting potential therapeutic targets for cancer.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Serglycin is a small proteoglycan characterized by Ser-Gly repeats and glycosaminoglycan side chains.
  • Intracellular serglycin influences the secretion of proteases and cytokines by binding them in secretory granules.
  • Extracellular serglycin is implicated in promoting metastasis of nasopharyngeal carcinoma cells.

Purpose of the Study:

  • To investigate the role of serglycin in cancer cell metastasis.
  • To explore the interaction between serglycin and CD44 in cancer progression.
  • To understand the mechanisms underlying serglycin-mediated metastasis.

Main Methods:

  • Analysis of serglycin's role in cancer cell secretion.
  • Investigation of serglycin binding to CD44.

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Published on: September 20, 2016

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Last Updated: May 29, 2026

Glycan Node Analysis: A Bottom-up Approach to Glycomics
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Published on: May 22, 2016

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

  • Study of glycosylation's impact on serglycin function in metastasis.

    • Main Results:

    • Extracellular serglycin promotes metastasis of nasopharyngeal carcinoma cells.
    • Serglycin binds to the cellular membrane glycoprotein CD44.
    • Glycosylation of serglycin's core protein is crucial for its metastasis-promoting function.

    Conclusions:

    • Serglycin plays a significant role in promoting cancer cell metastasis.
    • The interaction with CD44 and protein glycosylation are key mechanisms.
    • Targeting serglycin signaling pathways may offer strategies to prevent cancer metastasis.