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Updated: May 29, 2026
09:15
Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
Hormonal induction of endometrial receptivity
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA. RPaulson@USC.edu
Fertility and Sterility
|September 2, 2011
Summary
Estrogen and progesterone are essential for inducing endometrial receptivity for embryo implantation. This review synthesizes literature on hormonal treatments to optimize pregnancy outcomes in assisted reproductive technology.
Area of Science:
- Reproductive Endocrinology
- Assisted Reproductive Technology (ART)
Background:
- Third-party parenting in ART separates oocyte and endometrial development, enabling independent assessment.
- Endometrial receptivity is crucial for successful embryo implantation.
Purpose of the Study:
- To review and synthesize scientific literature on hormonal induction of endometrial receptivity prior to embryo transfer (ET).
Main Methods:
- Critical review and synthesis of selected scientific literature.
- Formulation of expert opinion based on evidence.
Main Results:
- Exogenous administration of estrogen (E2) and progesterone (P) can induce endometrial receptivity through various regimens.
- Synchrony between embryo and endometrium, controlled by initiating P stimulation timing, impacts implantation rates.
- The value of adjunct substances to E2 and P for enhancing endometrial receptivity remains unproven.
Conclusions:
- Estrogen and progesterone are the sole hormones required for preparing the endometrium for successful implantation.
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