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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Cellular oncomiR orthologue in EBV oncogenesis.

Sunil G Babu¹, Sanket Singh Ponia, Dinesh Kumar

¹Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, Uttar Pradesh, India. sunil_gos@yahoo.com

Computers in Biology and Medicine

|September 2, 2011

Summary

Epstein-Barr virus (EBV) encodes miR-BART-5, which shows sequence homology to human miR-18. This viral microRNA may act as an oncomiR, potentially influencing cellular growth in EBV-associated cancers.

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Separation of Immune Cell Subpopulations in Peripheral Blood Samples from Children with Infectious Mononucleosis

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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

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Published on: June 27, 2020

Area of Science:

Virology
Molecular Biology
Genomics

Background:

MicroRNAs (miRNAs) are key regulators of gene expression.
Virally encoded miRNAs play roles in viral replication and pathogenesis.
Kaposi's-sarcoma-associated herpesvirus encodes miRNAs, including an orthologue of human hsa-miR-155.

Purpose of the Study:

To investigate miRNA homology between humans and Epstein-Barr virus (EBV).
To explore the potential role of EBV-encoded miRNAs in pathogenesis, particularly in relation to human cancer-associated miRNAs.

Main Methods:

In silico miRNA-homology search between human and EBV miRNA sequences.
Analysis of potential mRNA targets for both viral and human miRNAs.
Comparison with known functions of human oncomiRs.

Main Results:

EBV-encoded miR-BART-5 exhibits significant 'seed' sequence homology to human hsa-miR-18.
Both miR-BART-5 and hsa-miR-18 can potentially target mRNA transcripts of human genes involved in cellular growth.
hsa-miR-18 is a known oncomiR.

Conclusions:

EBV-encoded miR-BART-5 may function as a viral oncomiR.
This viral oncomiR activity of miR-BART-5 is suggested by its homology to hsa-miR-18 and its potential to target cellular growth genes.
This finding is consistent with observations in EBV-positive gastric carcinoma patients.