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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Microbial Classification System01:24

Microbial Classification System

Classification is the process of organizing organisms into hierarchically inclusive groups based on their phenotypic similarities or evolutionary relationships. A species comprises one or more strains, and closely related species are grouped into genera. Genera are further classified into families, families into orders, orders into classes, and so forth, up to the domain level, which is the broadest taxonomic rank derived from a combination of phenotypic and genotypic data.The nomenclature of...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: May 29, 2026

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)
10:41

A Tuberculosis Molecular Bacterial Load Assay (TB-MBLA)

Published on: April 30, 2020

MtbSD--a comprehensive structural database for Mycobacterium tuberculosis.

Sameer Hassan1, P Logambiga, A Mohan Raman

  • 1National Institute for Research in Tuberculosis, Chetpet, Chennai 600 031, India.

Tuberculosis (Edinburgh, Scotland)
|September 2, 2011
PubMed
Summary
This summary is machine-generated.

The Mycobacterium tuberculosis Structural Database (MtbSD) provides crucial structural data for 857 proteins. This resource aids researchers in drug discovery and molecular modeling for tuberculosis.

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Area of Science:

  • Structural biology
  • Bioinformatics
  • Drug discovery

Background:

  • Tuberculosis (TB) remains a significant global health challenge.
  • Understanding Mycobacterium tuberculosis (M. tb) protein structures is vital for developing new treatments.
  • Existing databases may lack comprehensive structural information for M. tb proteins.

Purpose of the Study:

  • To introduce the Mycobacterium tuberculosis Structural Database (MtbSD) as a centralized resource.
  • To provide detailed structural information for M. tb proteins to facilitate research.
  • To support structure-based drug design efforts against TB.

Main Methods:

  • Development of a relational database (MtbSD).
  • Inclusion of data on protein descriptions, reactions, domains, active sites, and ligand interactions.
  • Curating information for all 857 available M. tb protein structures.

Main Results:

  • MtbSD contains comprehensive data for 857 M. tb protein structures.
  • Information includes protein characteristics, catalytic activities, and structural similarities.
  • The database links protein structures with bound and cognate ligands.

Conclusions:

  • MtbSD is a valuable resource for TB researchers.
  • Facilitates selection of protein-ligand complexes for molecular modeling and virtual screening.
  • Supports structure-based drug design for novel anti-TB agents.