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Identification of the myelin oligodendrocyte glycoprotein as a cellular receptor for rubella virus

Haolong Cong1, Yue Jiang, Po Tien

  • 1Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.

Journal of Virology
|September 2, 2011
PubMed

Insights

Researchers identified the myelin oligodendrocyte glycoprotein (MOG) as the cellular receptor for rubella virus (RV). Blocking MOG attachment may prevent RV infection, offering a new therapeutic strategy for rubella.

Area of Science:

  • Virology
  • Immunology
  • Neuroscience

Background:

  • Rubella virus (RV) causes significant health issues, including congenital rubella syndrome.
  • The cellular receptor for RV, crucial for understanding its entry mechanism, remained unidentified.
  • Identifying the RV receptor is vital for developing targeted interventions.

Purpose of the Study:

  • To identify the cellular receptor for rubella virus (RV).
  • To investigate the role of myelin oligodendrocyte glycoprotein (MOG) in RV infection.
  • To explore MOG as a potential target for blocking RV entry.

Main Methods:

  • Protein binding assays to test interactions between RV E1 glycoprotein and potential cellular receptors.
  • Neutralization assays using antibodies against MOG to block RV infection.
  • Genetic engineering to express MOG on non-permissive cells (293T) and assess RV replication.

Main Results:

  • Myelin oligodendrocyte glycoprotein (MOG) was found to specifically bind to the E1 envelope glycoprotein of RV.
  • An antibody targeting MOG effectively blocked RV infection in vitro.
  • Ectopic expression of MOG on 293T cells enabled RV entry and replication, confirming MOG's role as a functional receptor.

Conclusions:

  • Myelin oligodendrocyte glycoprotein (MOG) is identified as the cellular receptor for rubella virus (RV).
  • MOG facilitates RV entry into host cells.
  • Targeting the MOG-RV interaction presents a promising strategy for preventing or treating rubella infections.

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