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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Published on: February 28, 2012

Do preoperative statins reduce atrial fibrillation after coronary artery bypass grafting?

Hiroaki Sakamoto1, Yasunori Watanabe, Masataka Satou

  • 1Department of Cardiovascular Surgery, Hitachi General Hospital, Hitachi, Ibaraki, Japan. sakamotoh@md.tsukuba.ac.jp

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
|September 2, 2011
PubMed

Insights

Preoperative statin therapy significantly reduced the incidence of postoperative atrial fibrillation (AF) following coronary artery bypass grafting (CABG). This finding suggests statins may be beneficial in preventing AF after cardiac surgery.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Statins possess pleiotropic effects, including anti-inflammatory and potential atrial fibrillation (AF) preventive properties.
  • Postoperative AF is a common complication after coronary artery bypass grafting (CABG).

Purpose of the Study:

  • To evaluate the efficacy of preoperative statin therapy in mitigating the risk of AF subsequent to CABG.
  • To identify predictors of AF development after CABG.

Main Methods:

  • A retrospective analysis of 221 patients undergoing CABG between 2004 and 2007.
  • Patients were stratified into preoperative statin (n=77) and non-statin (n=126) groups, and into postoperative AF (n=54) and non-AF (n=149) groups.
  • Multivariate analysis was employed to determine independent predictors of postoperative AF.

Main Results:

  • The overall incidence of postoperative AF was 26%.
  • Patients receiving preoperative statin therapy exhibited a significantly lower incidence of postoperative AF (16%) compared to the non-statin group (33%, p=0.005).
  • Independent predictors for AF development included preoperative statin use (OR 0.327, p=0.05) and age (OR 1.058, p=0.035).

Conclusions:

  • Preoperative statin therapy appears to be an effective strategy for reducing the incidence of AF after CABG.
  • Statin therapy may play a protective role against the development of atrial fibrillation in the post-cardiac surgery setting.
Abstract

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