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Published on: February 27, 2026
Intrapulmonary-located Castleman's disease, which was surgically resected without pulmonary resection
Gulsah Gunluoglu1, Aysun Olcmen, Sinem Nedime Sokucu
1Department of Chest Diseases, Yedikule Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey. gunluoglugulsah@yahoo.com.tr
Summary
Castleman's disease (CD) is a rare condition causing benign lymph node hyperplasia. This case highlights CD arising from intrapulmonary lymph nodes, requiring surgical intervention for diagnosis and treatment.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Castleman's disease (CD) is a rare lymphoproliferative disorder of unknown etiology.
- It typically presents as generalized lymph node hyperplasia, commonly affecting the mediastinum and abdomen.
Observation:
- A 55 mm intrapulmonary mass with high contrast enhancement was identified in a 29-year-old male.
- Percutaneous biopsies were inconclusive, necessitating thoracotomy for diagnosis.
- The mass was found to originate from intrapulmonary lymph nodes.
Findings:
- Histopathological evaluation confirmed Castleman's disease involving intrapulmonary lymph nodes.
- This represents one of the few reported cases of intrapulmonary CD.
- Surgical resection was successfully performed, sparing the lung parenchyma.
Implications:
- Intrapulmonary Castleman's disease is rare and diagnostically challenging.
- Thoracotomy may be required for definitive diagnosis and treatment.
- Limited resection can be a viable option for intrapulmonary CD when benign, preserving lung function.
