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Updated: May 29, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
Unilateral GPi-DBS as a treatment for levodopa-induced respiratory dyskinesia in Parkinson disease
Genko Oyama1, Kelly D Foote, Sanjay S Iyer
1Department of Neurology, University of Florida Movement Disorders Center, Gainesville, FL 32610, USA.
Background:
Respiratory dyskinesia is a rare but disabling complication of levodopa therapy for Parkinson disease; however, its treatment has been limited to medication optimization.
Case Report:
A 72-year-old woman with a 6-year history of Parkinson disease presented with severe and debilitating levodopa-induced respiratory dyskinesia, which manifested with a short and shallow breathing pattern and panting. These symptoms were observed coincident with limb and truncal dyskinesias. Both respiratory and limb/trunk dyskinesias were addressed by the implantation of a unilateral globus pallidus interna deep brain stimulator (GPi-DBS).
Conclusions:
Although the mechanism of involvement of the respiratory system in dyskinesia is unknown, GPi-DBS seems to be a potentially viable treatment option for these patients.
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