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Related Experiment Video

Updated: May 29, 2026

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

LOX-1 and obesity.

Meiling Yan¹, Jawahar L Mehta, Changping Hu

¹Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, China.

Cardiovascular Drugs and Therapy

|September 2, 2011

Summary

This summary is machine-generated.

Obesity, a common disease linked to inflammation, involves Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1). This review explores LOX-1

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Area of Science:

Cardiovascular Science
Metabolic Disease Research
Molecular Biology

Background:

Obesity is a prevalent lifestyle disease linked to metabolic syndrome, insulin resistance, hypertension, dyslipidemia, and chronic inflammation.
It contributes to atherosclerosis and cardiovascular and renal diseases.
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a receptor for oxidized low-density lipoprotein (ox-LDL).

Purpose of the Study:

To review the current understanding of obesity and its complications.
To explore the relationship between LOX-1 and obesity.
To highlight LOX-1's role in obesity-related conditions.

Main Methods:

Literature review of studies on obesity and LOX-1.
Analysis of LOX-1 expression and function in obesity.
Synthesis of current knowledge on LOX-1's involvement in obesity pathogenesis.

Main Results:

LOX-1 is expressed in various cells, including endothelial cells, macrophages, and adipocytes.
LOX-1 plays a critical role in signal transduction and binds multiple ligands.
Upregulation of LOX-1 is increasingly recognized as a significant factor in obesity and its associated health issues.

Conclusions:

LOX-1 is implicated in the development of hypertension, diabetes mellitus, and hyperlipidemia, key risk factors for atherosclerosis.
LOX-1 upregulation is a vital factor in obesity and its complications.
Further research into LOX-1 may offer insights into managing obesity and related diseases.