Related Experiment Video

Updated: May 29, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Quality improvement guidelines for percutaneous catheter-directed intra-arterial thrombolysis and mechanical

Dimitris Karnabatidis1, Stavros Spiliopoulos, Dimitrios Tsetis

  • 1Department of Radiology, Patras University Hospital, School of Medicine, Rion, Greece. karnaby@med.upatras.gr

Cardiovascular and Interventional Radiology
|September 2, 2011
PubMed

Insights

Percutaneous catheter-directed intra-arterial thrombolysis is a safe treatment for acute lower limb ischemia. Mechanical thrombectomy offers an alternative when thrombolytics are contraindicated or rapid recanalization is needed.

Area of Science:

  • Vascular Surgery
  • Interventional Radiology

Background:

  • Acute and subacute lower limb ischemia pose significant clinical challenges.
  • Effective treatment is crucial to prevent limb loss and improve patient outcomes.

Purpose of the Study:

  • To evaluate the safety and efficacy of percutaneous catheter-directed intra-arterial thrombolysis (PTD) for lower limb ischemia.
  • To explore the role of mechanical thrombectomy as an adjunct or alternative therapy.

Main Methods:

  • Retrospective review of patients undergoing PTD for lower limb ischemia.
  • Analysis of procedural success rates, complication rates, and clinical outcomes.
  • Evaluation of mechanical thrombectomy in specific patient subgroups.

Main Results:

  • PTD demonstrated safety and effectiveness in treating acute and subacute lower limb ischemia with appropriate patient selection and monitoring.
  • Mechanical thrombectomy showed promise as a combined or standalone therapy for rapid recanalization or when thrombolytics are contraindicated.

Conclusions:

  • Percutaneous catheter-directed thrombolysis is a viable treatment option for lower limb ischemia.
  • Mechanical thrombectomy is a valuable alternative or adjunct therapy in selected cases, particularly when rapid reperfusion is essential or thrombolysis is contraindicated.

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

Related Concept Videos

Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...