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Updated: May 29, 2026
Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management
Published on: November 30, 2022
Sample collection, biobanking, and analysis
Maurice J Ahsman1, Dick Tibboel, Ron A A Mathot
1Department of Clinical Pharmacy, Erasmus MC, Rotterdam, The Netherlands.
Insights
Designing pediatric pharmacokinetic studies requires careful consideration of biofluid sampling methods, volumes, and storage. Adhering to safety guidelines and selecting appropriate assays ensures successful drug development in children.
Area of Science:
- Pharmacology
- Pediatric Research
- Bioanalytical Chemistry
Background:
- Pediatric pharmacokinetic studies are crucial for safe and effective drug use in children.
- Challenges include limited biofluid volumes, sampling frequency, and stringent patient safety guidelines.
- Existing research highlights the complexities in designing these studies.
Purpose of the Study:
- To provide practical guidance on biofluid sample collection and storage for pediatric pharmacokinetic studies.
- To address the selection of appropriate biofluid types and withdrawal techniques.
- To outline specimen storage considerations, including biobanking and drug assay requirements.
Main Methods:
- Review of practical implications for sample collection and storage in pediatric research.
- Focus on selection criteria for biofluid types and withdrawal techniques.
- Discussion of specimen storage protocols and drug assay method requirements.
Main Results:
- Successful pediatric pharmacokinetic studies are feasible with meticulous planning.
- Careful selection of sampling methods, specimen volume, and assay techniques is essential.
- A provided checklist can aid researchers in protocol and infrastructure design.
Conclusions:
- Pediatric pharmacokinetic studies necessitate specialized approaches to biofluid sampling and handling.
- Optimizing study design through careful method selection enhances data reliability and patient safety.
- The chapter offers a framework to support researchers in conducting pediatric drug studies.
Abstract:
Pediatric pharmacokinetic studies require sampling of biofluids from neonates and children. Limitations on sampling frequency and sample volume complicate the design of these studies. In addition, strict guidelines, designed to guarantee patient safety, are in place. This chapter describes the practical implications of sample collection and their storage, with special focus on the selection of the appropriate type of biofluid and withdrawal technique. In addition, we describe appropriate measures for storage of these specimens, for example, in the context of biobanking, and the requirements on drug assay methods that they pose. Pharmacokinetic studies in children are possible, but they require careful selection of an appropriate sampling method, specimen volume, and assay method. The checklist provided could help prospective researchers with the design of an appropriate study protocol and infrastructure.
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