Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 29, 2026

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

Published on: March 2, 2016

Silica shell/gold core nanoparticles: correlating shell thickness with the plasmonic red shift upon aggregation.

Alan Vanderkooy¹, Yang Chen, Ferdinand Gonzaga

¹Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4M1.

ACS Applied Materials & Interfaces

|September 3, 2011

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Tuning the viscoelasticity of sugar-silicone polymers using caramelization.

Chemical communications (Cambridge, England)·2026

Same author

Strategies to Improve the Sustainability of Silicone Polymers.

Macromolecules·2025

Same author

Functional silicone oils and elastomers: new routes lead to new properties.

Chemical communications (Cambridge, England)·2023

Same author

Exploring Lipoic Acid-Mediated Dynamic Bottlebrush Elastomers as a New Platform for the Design of High-Performance Thermally Conductive Materials.

ACS applied materials & interfaces·2023

Same author

Antioxidant Silicone Elastomers without Covalent Cross-Links.

ACS sustainable chemistry & engineering·2023

Same author

Preparation of ultra-thin elastomeric films.

The European physical journal. E, Soft matter·2023

Silica shells on gold nanoparticles improve bioassay stability by preventing ligand exchange and biomolecule adsorption. Shell thickness impacts aggregated particle color, offering tunable properties for colorimetric assays.

Area of Science:

Nanotechnology
Materials Science
Analytical Chemistry

Background:

Gold nanoparticles (AuNP) are vital for bioassays, but their surfaces face challenges like ligand exchange and nonspecific adsorption.
Silica shells offer a solution by enhancing surface chemistry and preventing these issues.

Purpose of the Study:

To investigate the synthesis of silica shells on gold nanoparticles.
To evaluate the impact of silica shell thickness on the optical properties of gold nanoparticles, particularly their aggregation-induced color changes.

Main Methods:

Synthesized silica shells on gold nanoparticles using tetraethyl orthosilicate under basic conditions (controlled growth, 1.7-4.3 nm) and diglyceroxysilane at neutral pH (rapid formation, 3-4 nm).
Measured absorbance spectra of unaggregated and aggregated silica-coated gold nanoparticles to assess optical property changes.

More Related Videos

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Published on: February 11, 2016

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Published on: August 15, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

Published on: March 2, 2016

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Generation of Zerovalent Metal Core Nanoparticles Using n-(2-aminoethyl)-3-aminosilanetriol

Published on: February 11, 2016

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Photodeposition of Pd onto Colloidal Au Nanorods by Surface Plasmon Excitation

Published on: August 15, 2019

Main Results:

Silica shells did not significantly alter the absorbance maximum of unaggregated gold nanoparticles.
The change in absorbance wavelength upon aggregation was highly dependent on silica shell thickness.
Increased shell thickness (1.7-4.3 nm) led to a decrease in the aggregated particle absorbance maximum (578 nm to 536 nm) due to increased interparticle distance.

Conclusions:

Silica coating provides a stable platform for gold nanoparticles in bioassays.
The thickness of silica shells can be controlled to tune the optical response of aggregated gold nanoparticles.
These findings guide the development of advanced colorimetric assays utilizing silica-coated gold nanoparticles.