Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Long-term outcomes and late effects of surgery and radiotherapy in adult intracranial ependymoma patients.

Journal of neuro-oncology·2026

Same author

Empowering Neurosurgical Leadership: Training the Next Generation of Neurosurgical Leaders.

Neurosurgery·2026

Same author

Use of a Novel Intraoperative Neurocognitive Monitoring Task During Awake Craniotomy for Tumor Resection in the Language-Dominant Parietal Lobe.

Operative neurosurgery (Hagerstown, Md.)·2026

Same author

Cognitive function, quality of life, and survival outcomes in patients with lower grade gliomas treated with proton radiation therapy: A phase II study.

Neuro-oncology·2026

Same author

Protocol for the systematic reduction of sterile surgical instrument waste: a single-institution prospective implementation and analysis.

Journal of neurosurgery·2026

Same author

Extent of resection and adjuvant treatment in adult cerebellar glioblastoma: systematic review and meta-analysis of survival outcomes.

Journal of neuro-oncology·2025

Search research articles

Related Experiment Video

Updated: May 29, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Familial Chiari malformation: case series.

Benjamin D Schanker¹, Brian P Walcott, Brian V Nahed

¹Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, 02114, USA.

Neurosurgical Focus

|September 3, 2011

Summary

This summary is machine-generated.

Familial Chiari malformation, a brain abnormality affecting the cerebellum, shows genetic links. This study examines three families with Chiari malformation Type I, highlighting the need for further genetic research.

More Related Videos

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

Related Experiment Videos

Last Updated: May 29, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model

Published on: November 4, 2025

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

Published on: September 4, 2017

Area of Science:

Neuroscience
Medical Genetics

Background:

Chiari malformations (Types I-IV) are posterior fossa abnormalities impacting the cerebellum, brainstem, and spinal cord.
Prevalence ranges from 0.1% to 0.5% globally.
Evidence suggests a genetic basis for familial Chiari malformation, supported by twin studies and genetic association research.

Observation:

The study reports on three family pairs diagnosed with Chiari malformation Type I.
Two pairs involved mother-daughter transmission, and one pair involved father-daughter transmission.
This familial aggregation provides further evidence for genetic factors in Chiari malformation.

Findings:

The precise genetic causes of familial Chiari malformation remain largely unknown.
Several candidate genes are discussed in the literature review.
Understanding genetic influences is crucial for elucidating pathogenesis.

Implications:

Advances in understanding genetic influences are expected to enhance patient management.
Improved knowledge will aid in monitoring at-risk family members.
Further research into the genetic underpinnings of Chiari malformation is warranted.