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Published on: October 28, 2015
Using C60 fullerenes for photodynamic inactivation of mosquito iridescent viruses
Yu Rud1, L Buchatskyy, Yu Prylutskyy
1Kyiv National Taras Shevchenko University, Institute of Biology, Kyiv, Ukraine.
Abstract:
This article describes the photodynamic inactivation of mosquito iridescent virus (MIV) Aedes flavescens in the presence of water-soluble C(60) fullerenes. It has been observed that the photodynamic inactivation of MIV for about 1 h reduces the infectious titre of the virus in large wax-moth larvae Galleria mellonella to 4.5 lg ID(50)/mL. The influence of the C(60) concentration on its anti-viral activity was tested in the concentration range from 1 to 0.001 mg/mL. It has been found that C(60) is able to inactivate the iridovirus even in low concentrations. Consequently, the findings of this work suggest that photoexcited C(60) fullerenes can be successfully used for the inactivation of iridoviruses in biological systems.
Insights
Photodynamic inactivation effectively reduces mosquito iridescent virus (MIV) using C(60) fullerenes. This antiviral strategy shows promise for MIV inactivation in biological systems, even at low fullerene concentrations.
Area of Science:
- Virology
- Nanotechnology
- Photochemistry
Background:
- Mosquito iridescent virus (MIV) poses a threat to insect populations.
- Photodynamic inactivation is a potential antiviral strategy.
- Fullerenes, particularly C(60), have shown photosensitizing properties.
Purpose of the Study:
- To investigate the photodynamic inactivation of MIV using water-soluble C(60) fullerenes.
- To determine the efficacy of C(60) fullerenes in reducing MIV infectious titre.
- To assess the impact of C(60) concentration on antiviral activity.
Main Methods:
- Photodynamic inactivation of MIV was performed in the presence of varying concentrations of C(60) fullerenes.
- Infectious titre reduction was measured in Galleria mellonella larvae.
- Antiviral activity was evaluated across a C(60) concentration range of 1 to 0.001 mg/mL.
Main Results:
- Photodynamic treatment with C(60) fullerenes reduced MIV infectious titre to 4.5 lg ID(50)/mL after 1 hour.
- C(60) fullerenes demonstrated antiviral activity even at low concentrations.
- The concentration of C(60) influenced the extent of MIV inactivation.
Conclusions:
- Photoexcited C(60) fullerenes are effective in the photodynamic inactivation of MIV.
- This method shows potential for controlling iridoviruses in biological systems.
- Low concentrations of C(60) are sufficient for significant viral inactivation.
