Related Experiment Video

Updated: May 29, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Coexistent granulomatous vasculitis and leukaemia cutis in a patient with resolving herpes zoster

M Elgoweini1, K Blessing, R Jackson

  • 1Department of Pathology, North Glasgow University Hospitals NHS Trust, Glasgow, UK. mahaelgoweini@doctors.org.uk

Clinical and Experimental Dermatology
|September 3, 2011
PubMed

Insights

This study reports a rare case of small lymphocytic lymphoma (SLL) koebnerization presenting as granulomatous vasculitis following herpes zoster (HZ) infection. It emphasizes the need for thorough investigation to differentiate benign reactions from true lymphomas.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Small lymphocytic lymphoma (SLL) is a low-grade B-cell lymphoma.
  • Herpes zoster (HZ) is a viral infection causing a painful rash.
  • Postherpetic granulomatous reactions can mimic other skin conditions.

Observation:

  • An 80-year-old man with SLL developed indurated purple papules and plaques post-HZ infection.
  • Skin biopsy revealed granulomatous vasculitis and a monoclonal B-cell infiltrate.
  • The findings suggest SLL koebnerization in the context of a post-HZ reaction.

Findings:

  • Concurrent granulomatous vasculitis and SLL koebnerization post-HZ is a novel finding.
  • Distinguishing benign pseudolymphomas from true lymphomas is crucial.
  • Histopathology, immunocytochemistry, and molecular studies are vital for diagnosis.

Implications:

  • This case underscores the importance of clinicopathological correlation in complex dermatological presentations.
  • It highlights that true lymphomas can occur even with seemingly benign vasculitic features.
  • Accurate diagnosis is essential for appropriate management of SLL and post-HZ complications.

More Related Videos

Granulocyte-dependent Autoantibody-induced Skin Blistering12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Concept Videos

Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Leishmaniasis01:30

Leishmaniasis

Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...