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Antioxidant status in patients with lichen planus
B Barikbin1, M Yousefi, H Rahimi
1Skin Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical and Experimental Dermatology
|September 3, 2011
Summary
Patients with lichen planus (LP) have significantly lower serum vitamin C levels, suggesting oxidative stress contributes to this autoimmune skin condition. Antioxidant levels like vitamin C may play a role in LP pathogenesis.
Area of Science:
- Dermatology
- Immunology
- Oxidative Stress Research
Background:
- Lichen planus (LP) is an autoimmune mucocutaneous disease with an unclear pathological pathway.
- Reactive oxygen species (ROS) and antioxidants are implicated in autoimmune skin disorders.
Purpose of the Study:
- To investigate serum antioxidant levels in lichen planus patients.
- To compare antioxidant levels between LP patients and healthy controls.
Main Methods:
- 30 untreated LP patients and 30 healthy controls were enrolled.
- Serum levels of glutathione peroxidase (GPX), vitamin C, selenium, bilirubin, and uric acid were measured.
Main Results:
- Vitamin C levels were significantly lower in LP patients compared to controls (P < 0.001).
- A strong positive correlation between selenium and GPX was observed in both groups.
Conclusions:
- Reduced serum vitamin C in LP patients suggests oxidative damage is a key factor in disease development.
- Further research into antioxidant therapies for lichen planus is warranted.
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