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Related Experiment Video

Updated: May 29, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Invasive group B streptococcal infections in adults, France (2007-2010).

A Tazi¹, P C Morand, H Réglier-Poupet

¹Centre National de Référence des Streptocoques (CNR-Strep), Groupe Hospitalier Cochin-Hôtel Dieu-Broca Assistance Publique Hôpitaux de Paris, Paris, France.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases

|September 3, 2011

Summary

Group B Streptococcus (GBS) causes serious adult infections, primarily bloodstream and bone/joint infections. Erythromycin resistance in GBS strains is rising, particularly in type V, linked to the erm(B) gene.

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Last Updated: May 29, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

Area of Science:

Infectious Diseases
Microbiology
Clinical Medicine

Background:

Group B Streptococcus (GBS) is an increasing cause of invasive infections in adults.
Understanding GBS epidemiology and resistance patterns is crucial for effective treatment.

Purpose of the Study:

To characterize the clinical and microbiological features of adult GBS invasive infections.
To analyze trends in GBS capsular polysaccharide (CPS) types and antibiotic resistance over a four-year period.

Main Methods:

Retrospective analysis of 401 non-redundant GBS strains from adult invasive infections (2007-2010).
Clinical data collection and microbiological characterization, including CPS typing and antibiotic susceptibility testing.

Main Results:

The most common clinical presentations were bacteremia without a clear focus (43.4%) and bone and joint infections (18.7%).
Capsular polysaccharide types Ia, III, and V comprised 71.8% of the isolates.
Erythromycin resistance increased significantly from 20.2% in 2007 to 35.3% in 2010.
Erythromycin resistance was predominantly associated with CPS type V strains carrying the erm(B) determinant.

Conclusions:

GBS causes significant invasive disease in adults, with distinct clinical and serotype profiles.
The rising erythromycin resistance in GBS, especially in type V, necessitates ongoing surveillance and may impact treatment options.