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A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
10:26

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational

M Dennis1, N Mordi, C Graham

  • 1Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, UK. martin.dennis@ed.ac.uk

Journal of Thrombosis and Haemostasis : JTH
|September 3, 2011
PubMed

Insights

Deep vein thrombosis (DVT) in stroke patients is common, with over 14% developing it. Prophylaxis for deep vein thrombosis should be initiated early and maintained for at least four weeks.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Medical Imaging

Background:

  • Deep vein thrombosis (DVT) is a significant complication following stroke.
  • Evidence supporting prophylactic strategies for DVT in stroke patients is often conflicting.

Purpose of the Study:

  • To determine the incidence and extent of DVT in immobile stroke patients.
  • To identify clinical features associated with DVT post-stroke.
  • To describe the natural evolution of DVT in this population.

Main Methods:

  • Utilized data from the CLOTS trials 1 and 2, involving 5632 immobile stroke patients across 135 hospitals in nine countries.
  • Employed compression duplex ultrasound (CDU) for screening asymptomatic DVT at approximately 7-10 days and 25-30 days post-enrollment.

Main Results:

  • A total of 11.4% of patients developed DVT within the first week, with an additional 3.1% developing it by day 28.
  • Of DVTs detected, 35% were symptomatic, and 5% were associated with pulmonary embolism (PE).
  • DVT distribution varied, with 39% limited to calf veins and 40% involving femoral veins; 47% of early DVTs regressed, 44% remained stable, and 9% progressed.

Conclusions:

  • Deep vein thrombosis in stroke patients can manifest both early and late, with some cases progressing over time.
  • Current prophylactic strategies for DVT require early initiation.
  • Prophylaxis for deep vein thrombosis should ideally extend for a minimum of four weeks to address the evolving risk.
Abstract

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