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Related Concept Videos

The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Regulation of the Unfolded Protein Response

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Related Experiment Video

Updated: May 29, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Sensing damage by the NLRP3 inflammasome.

Jaklien C Leemans1, Suzanne L Cassel, Fayyaz S Sutterwala

  • 1Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Immunological Reviews
|September 3, 2011
PubMed
Summary

The NLRP3 inflammasome, crucial for host defense, activates caspase-1 to release inflammatory cytokines IL-1β and IL-18. Its dysregulation is linked to inflammatory diseases.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pathogenesis

Background:

  • The NLRP3 inflammasome is a key mediator of innate immunity.
  • It responds to danger signals like tissue damage, metabolic stress, and infection.
  • Activation leads to caspase-1 processing and release of IL-1β and IL-18.

Purpose of the Study:

  • To review recent advancements in understanding NLRP3 inflammasome activation mechanisms.
  • To explore the role of NLRP3 inflammasome in the development of inflammatory diseases.

Main Methods:

  • Literature review of recent studies on NLRP3 inflammasome.
  • Analysis of molecular pathways involved in inflammasome activation.
  • Examination of disease models associated with NLRP3 inflammasome dysregulation.

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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

Related Experiment Videos

Last Updated: May 29, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

Evaluation of Caspase Activation to Assess Innate Immune Cell Death
10:23

Evaluation of Caspase Activation to Assess Innate Immune Cell Death

Published on: January 20, 2023

Main Results:

  • New insights into the triggers and signaling pathways of NLRP3 inflammasome activation.
  • Evidence linking dysregulated NLRP3 inflammasome activity to various inflammatory conditions.
  • Identification of specific molecular players in inflammasome assembly and function.

Conclusions:

  • NLRP3 inflammasome activation is a tightly regulated process with significant implications for health and disease.
  • Understanding its mechanisms is vital for developing targeted therapies for inflammatory diseases.
  • Further research is needed to fully elucidate its complex role in pathogenesis.