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Updated: May 29, 2026

A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans
Published on: October 16, 2015
Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative
Marco Gallo1, Donha Park, Donald L Riddle
1Department of Medical Genetics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada. mgallo@msl.ubc.ca
Abstract:
The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.
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