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14-3-3 Proteins: diverse functions in cell proliferation and cancer progression

Alyson K Freeman1, Deborah K Morrison

  • 1Laboratory of Cell and Developmental Signaling, NCI-Frederick, P.O. Box B, Frederick, MD 21702, United States.

Seminars in Cell & Developmental Biology
|September 3, 2011
PubMed

Insights

14-3-3 proteins regulate vital cellular processes by binding to phosphoserine/phosphothreonine. Dysregulation of these proteins is implicated in cancer, influencing cell proliferation and migration.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Cancer Biology

Background:

  • 14-3-3 proteins are the primary phosphoserine/phosphothreonine-binding proteins.
  • They play a crucial role in cell signaling by interacting with diverse protein targets.
  • These interactions are fundamental to cellular processes and are often dysregulated in cancer.

Purpose of the Study:

  • To review recent advances in understanding 14-3-3 proteins' roles in normal growth and cancer.
  • To emphasize signaling pathways affected by 14-3-3 proteins in cell proliferation, migration, and epithelial-to-mesenchymal transition.

Main Methods:

  • Literature review of recent scientific advances.
  • Focus on signaling pathways impacting key cellular processes.

Main Results:

  • 14-3-3 proteins modulate target protein localization, stability, conformation, phosphorylation, activity, and interactions.
  • These proteins are key regulators in cell proliferation, migration, and epithelial-to-mesenchymal transition.

Conclusions:

  • 14-3-3 proteins are central regulators of vital cellular processes.
  • Their dysregulation is linked to cancer development and progression, particularly affecting cell migration and proliferation.

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