Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aging and monoamine receptors in brain.

M H Makman, H S Ahn, L J Thal

    Federation Proceedings
    |April 1, 1979
    PubMed
    Summary

    Aging rabbits show reduced dopamine and histamine receptor activity in key brain areas. This age-related decline in biogenic amine receptors may contribute to cognitive impairment, independent of neuronal loss.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multiancestry Genome-Wide Association Study of Early Childhood Caries.

    Journal of dental research·2024
    Same author

    Multi-ancestry Genome-Wide Association Study of Early Childhood Caries.

    medRxiv : the preprint server for health sciences·2024
    Same author

    Comparison of sentinel lymph node biopsy and elective neck dissection for early oral cavity squamous cell carcinoma patients with clinically node-negative necks: systematic review and meta-analysis.

    The Journal of laryngology and otology·2022
    Same author

    Familial risk for endometriosis and its interaction with smoking, age at menarche and body mass index: a population-based cohort study among siblings.

    BJOG : an international journal of obstetrics and gynaecology·2021
    Same author

    Response to 'The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population-based matched cohort study in Korea' - reply from the authors.

    The British journal of dermatology·2020
    Same author

    Incidence, survival, and risk of cardiovascular events in adult inflammatory myopathies in South Korea: a nationwide population-based study.

    Scandinavian journal of rheumatology·2020

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Aging Research

    Background:

    • Biogenic amine receptor systems play crucial roles in brain function.
    • Age-related changes in these systems are implicated in cognitive decline.
    • Previous research suggests alterations in neurotransmitter systems with aging.

    Purpose of the Study:

    • To investigate age-dependent changes in biogenic amine receptor systems in the rabbit brain.
    • To determine if these changes affect receptor number or affinity.
    • To explore the relationship between receptor changes and neuronal integrity.

    Main Methods:

    • Assessed dopamine- and histamine-stimulated adenylate cyclase activity in various brain regions of young and aged rabbits.
    • Measured the binding of [3H]spiroperidol, a dopamine antagonist, to assess receptor binding sites and affinity.
    • Quantified dopamine concentration and choline acetylase activity to evaluate neuronal function.

    Main Results:

    • Dopamine-stimulated adenylate cyclase activity decreased by approximately 50% in striatum, hypothalamus, and cortical regions with age.
    • Histamine-stimulated activity showed similar age-related declines in the hypothalamus and cortex.
    • The number of dopamine receptor binding sites decreased by 30-40% in the striatum and limbic cortex, without changes in affinity.
    • These receptor changes occurred independently of alterations in dopamine concentration or choline acetylase activity.

    Conclusions:

    • Selective, age-dependent decreases in functional biogenic amine receptors occur in specific brain regions.
    • These declines appear to be independent of neuronal cell loss, possibly mediated by desensitization.
    • The observed changes in rabbit brain regions homologous to human areas involved in cognitive function suggest a potential mechanism for age-related cognitive decline.

    Related Experiment Videos