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Solvent nephrotoxicity in humans and experimental animals
N A Nelson1, T G Robins, F K Port
1Department of Epidemiology, University of Michigan, Ann Arbor.
American Journal of Nephrology
|January 1, 1990
Abstract:
Evidence from human case reports, epidemiologic studies and animal experiments have suggested that exposure to organic solvents is associated with a wide spectrum of renal disorders, including tubular necrosis, interstitial disease, glomerulonephritis and neoplasia. This review summarizes what is known about solvent-induced renal damage in humans and experimental animals, with emphasis on hypothesized mechanisms by which this broad range of disorders may occur.