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Updated: May 29, 2026
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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Monitoring tumor motion by real time 2D/3D registration during radiotherapy
Christelle Gendrin1, Hugo Furtado, Christoph Weber
1Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Summary
This study shows that real-time X-ray based 2D/3D registration can monitor non-invasive tumor motion during radiotherapy. This markerless registration method is feasible for improving treatment accuracy.
Area of Science:
- Medical Physics
- Radiotherapy Technology
- Image-guided Interventions
Background:
- Accurate tumor targeting in radiotherapy requires accounting for organ motion.
- Non-invasive methods for real-time motion monitoring are crucial for adaptive radiotherapy.
Purpose of the Study:
- To investigate the feasibility of using X-ray based real-time 2D/3D registration for non-invasive tumor motion monitoring.
- To evaluate the accuracy and speed of this registration technique.
Main Methods:
- Implementation of a 2D/3D registration scheme using general-purpose computation on graphics hardware (GPGPU).
- Algorithmic refinements in the registration process.
- Validation using phantom and clinical patient data, focusing on the region of interest (ROI) around the planned target volume (PTV).
Main Results:
- Phantom motion measured with a root-mean-square (rms) error of 2.56 mm.
- Patient data revealed sinusoidal motion correlated with breathing cycles.
- Mean registration time achieved was 0.5 seconds, with good visual correlation between X-ray and digitally reconstructed radiographs (DRR) displacement.
Conclusions:
- Real-time organ motion monitoring during radiotherapy is feasible using image-based markerless registration.
- X-ray based 2D/3D registration offers a promising approach for non-invasive tumor motion tracking.
