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Related Experiment Video

Updated: May 29, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

[Measles and pregnancy].

Olivia Anselem¹, Vassilis Tsatsaris, Emmanuel Lopez

¹Faculté de médecine, université Paris-Descartes, Paris, France.

Presse Medicale (Paris, France : 1983)

|September 3, 2011

Summary

This summary is machine-generated.

Measles outbreaks increase risks for pregnant women and infants. Vaccination before pregnancy or post-partum is crucial for preventing severe maternal and fetal complications, including death.

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Last Updated: May 29, 2026

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)

Published on: March 25, 2016

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Area of Science:

Virology
Obstetrics
Public Health

Context:

Measles outbreaks in France since 2008 due to insufficient vaccine coverage.
Increased incidence among children under 1 year and young adults.
Measles during pregnancy poses significant risks to both mother and fetus.

Purpose:

To highlight the increased maternal and fetal morbidity associated with measles during pregnancy.
To outline the risks of placental infection, fetal death, miscarriage, and prematurity.
To recommend preventive and therapeutic strategies for measles in pregnant women and neonates.

Summary:

Measles infection during pregnancy can lead to severe maternal respiratory distress and death.
Placental infection by the measles virus can cause fetal death and histologic damage, but not congenital defects.
Perinatal risks include miscarriage, prematurity, and congenital infection with potential for subacute sclerosing panencephalitis.

Impact:

Immunoglobulin prophylaxis is recommended for non-immune pregnant women and neonates exposed to measles.
Symptomatic treatment, tocolysis, and daily fetal monitoring are suggested for infected pregnant women.
Measles vaccination (2 doses) is recommended for individuals born after 1980 in France, ideally before pregnancy or postpartum.