Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 29, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Functional connectivity targeting for deep brain stimulation in essential tremor.

J S Anderson1, H S Dhatt, M A Ferguson

  • 1Division of Neuroradiology, University of Utah School of Medicine, Salt Lake City, 84132, USA. andersonjeffs@gmail.com

AJNR. American Journal of Neuroradiology
|September 3, 2011
PubMed
Summary

Functional connectivity mapping precisely identifies individualized deep brain stimulation targets in the thalamus for essential tremor, improving neurostimulator placement accuracy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.

Developmental cognitive neuroscience·2026
Same author

A randomised controlled clinical trial to assess the benefits of a telecare tool delivered prior to the initial hearing assessment.

International journal of audiology·2022
Same author

Anatomical and fMRI-network comparison of multiple DLPFC targeting strategies for repetitive transcranial magnetic stimulation treatment of depression.

Brain stimulation·2021
Same author

Targeting location relates to treatment response in active but not sham rTMS stimulation.

Brain stimulation·2021
Same author

Increased Functional Connectivity After Listening to Favored Music in Adults With Alzheimer Dementia.

The journal of prevention of Alzheimer's disease·2018
Same author

Multivariate characterization of white matter heterogeneity in autism spectrum disorder.

NeuroImage. Clinical·2017

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Neurosurgery

Background:

  • Deep brain stimulation (DBS) of the thalamus is effective for essential tremor.
  • Current targeting methods do not fully account for individual anatomical differences.
  • Precise targeting is crucial for optimal neurostimulator placement.

Purpose of the Study:

  • To investigate if functional connectivity measurements can identify precise DBS targets in the thalamus.
  • To assess the utility of functional connectivity for image-guided neurostimulator placement.
  • To account for individual anatomical variability in thalamic DBS targeting.

Main Methods:

  • Resting-state BOLD images were acquired from 58 healthy volunteers.
  • Regions of interest were defined in the motor cortex and superior cerebellum.

More Related Videos

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

Related Experiment Videos

Last Updated: May 29, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
05:54

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor

Published on: December 13, 2017

  • Thalamic voxel time series correlations were analyzed to map functional connectivity.

    • Main Results:

    • Group average connectivity maps precisely localized targets within the ventral intermediate nucleus of the thalamus.
    • Individualized targets were identified with single-voxel accuracy using 3 hours of imaging.
    • Target locations varied between individuals and group averages, highlighting interindividual variability.

    Conclusions:

    • Optimal thalamic DBS target placement for essential tremor likely varies between individuals.
    • Individualized thalamic targets can be accurately estimated using functional connectivity and sufficient imaging time.
    • This approach offers improved image guidance for neurostimulator placement in essential tremor.