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The burden of disease in pediatric non-cystic fibrosis bronchiectasis

Nitin Kapur1, I Brent Masters2, Peter Newcombe3

  • 1Department of Respiratory Medicine and the Queensland Children's Medical Research Institute, Royal Children's Hospital, Herston, QLD, Australia; Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.

Chest
|September 3, 2011
PubMed

Insights

Children with non-CF bronchiectasis face significant burdens, particularly during exacerbations. Managing these events is key to improving quality of life and parental mental health in pediatric bronchiectasis patients.

Area of Science:

  • Pediatric Pulmonology
  • Child Health Outcomes
  • Respiratory Medicine

Background:

  • The disease burden in children with non-cystic fibrosis (non-CF) bronchiectasis remains largely unknown.
  • Quality of life (QOL) and parental mental health are critical aspects of managing pediatric chronic respiratory conditions.

Purpose of the Study:

  • To identify factors influencing QOL and parental mental health in children with non-CF bronchiectasis.
  • To assess the impact of disease exacerbations on these parameters in pediatric patients.

Main Methods:

  • Prospective study involving parents of 69 children with non-CF bronchiectasis.
  • Utilized parent-proxy cough-specific QOL (PC-QOL) and Depression, Anxiety, and Stress Scale (DASS) questionnaires during stable and exacerbation states.
  • Collected clinical, investigational, and lung function data.

Main Results:

  • Younger age correlated with worse QOL in stable states; other factors like lung function or cause did not significantly impact QOL.
  • Exacerbations led to significant worsening of PC-QOL scores and DASS scores, indicating increased parental stress and anxiety.
  • During exacerbations, 38% reported elevated anxiety and 54% abnormal depression/stress scores.

Conclusions:

  • Children with non-CF bronchiectasis experience a substantial disease burden, especially during exacerbations.
  • Parental mental health is significantly affected during exacerbations.
  • Effective prevention, early detection, and treatment of exacerbations are crucial for reducing psychologic morbidity in affected families.
Abstract

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