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Related Experiment Video

Updated: May 29, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

Efficiency perspectives on adaptive designs in stroke clinical trials.

Ken Cheung1, Petra Kaufmann

  • 1Department of Biostatistics, Columbia University, 722 W 168th Street, New York, NY 10032, USA. yc632@columbia.edu

Stroke
|September 3, 2011
PubMed
Summary

Adaptive clinical trial designs offer statistical efficiency by adjusting studies with interim data. However, these designs incur hidden costs and trade-offs, impacting stakeholder perspectives and trial deployment strategies.

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Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...

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Area of Science:

  • Clinical Trials
  • Biostatistics
  • Neurology

Background:

  • Adaptive designs allow real-time modifications to clinical studies based on interim data analysis.
  • The primary goal is to enhance statistical efficiency and maximize information from clinical data.

Purpose of the Study:

  • To review commonly used adaptive strategies in early-phase stroke trials.
  • To discuss the associated costs and trade-offs of these adaptive designs.

Main Methods:

  • Illustrating trade-offs in dose-finding (NeuSTART trial), futility analyses, and internal pilot studies.
  • Examining sample size considerations in imaging-based dose-selection trials.

Main Results:

  • Adaptive designs present potential tensions between individual investigator and broader stakeholder interests.

Related Experiment Videos

Last Updated: May 29, 2026

Computerized Adaptive Testing System of Functional Assessment of Stroke
05:21

Computerized Adaptive Testing System of Functional Assessment of Stroke

Published on: January 7, 2019

  • The costs associated with adaptive designs are often not explicitly stated in the literature.

    • Conclusions:

    • Understanding the limitations and full promise of adaptive designs is crucial for appropriate statistical design selection.
    • Investigators must consider both efficiency gains and inherent costs when choosing adaptive or traditional trial designs.