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Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
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Updated: May 29, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
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Published on: February 19, 2019

Staphylococcus lugdunensis: an emerging pathogen.

Alyona Klotchko1, Mark R Wallace, Carmelo Licitra

  • 1Department of Internal Medicine, Orlando Health, FL, USA.

Southern Medical Journal
|September 3, 2011
PubMed
Summary
This summary is machine-generated.

Staphylococcus lugdunensis is an emerging pathogen causing significant infections, including soft tissue, bone, and bloodstream infections. This bacterium should not be dismissed as a contaminant without thorough evaluation.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases

Background:

  • Emerging bacterial pathogens pose challenges in clinical settings.
  • Staphylococcus lugdunensis is increasingly recognized for its clinical significance.

Observation:

  • A retrospective review identified 77 Staphylococcus lugdunensis isolates over three years.
  • Infections included soft tissue abscesses, osteomyelitis, prosthetic joint infections, and bacteremia.

Findings:

  • Staphylococcus lugdunensis caused diverse infections, notably endocarditis in 5 bacteremic cases, with 2 fatalities.
  • The majority of isolates exhibited penicillin resistance.
  • Clinical data confirmed S. lugdunensis as a pathogen causing severe infections.

Implications:

  • Staphylococcus lugdunensis is a significant pathogen requiring careful clinical consideration.
  • Misidentification as a contaminant could lead to delayed or inadequate treatment.
  • Further research into S. lugdunensis pathogenesis and treatment is warranted.