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Effect of hepatitis C virus infection on the left ventricular systolic and diastolic functions

Mehmet Demir1, Canan Demir

  • 1Department of Cardiology, Bursa Yüksek İhtisas Education and Research Hospital, Bursa, Turkey. drmehmetdemir@hotmail.com

Southern Medical Journal
|September 3, 2011
PubMed

Insights

Hepatitis C virus (HCV) infection may impact heart function, potentially causing left ventricular systolic and diastolic dysfunction. This study investigated cardiac function in HCV patients, revealing significant differences compared to healthy individuals.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Hepatology

Background:

  • Hepatitis C virus (HCV) infection is a global health concern.
  • HCV is linked to various extrahepatic manifestations.
  • Cardiac involvement, specifically cardiomyopathy, has been noted in HCV patients, but effects on ventricular function were unclear.

Purpose of the Study:

  • To assess left ventricular systolic and diastolic functions in patients with Hepatitis C virus infection.
  • To identify potential cardiac dysfunction associated with HCV.

Main Methods:

  • Transthoracic echocardiography and P-wave analysis were performed on 50 anti-HCV positive patients and 50 controls.
  • Left ventricle diastolic parameters, ejection fraction, and P-wave dispersion (Pd) were compared between groups.

Main Results:

  • HCV patients showed a lower E/A ratio (1.2 vs. 1.37) and a higher E/Em ratio (7.6 vs. 6.8), indicating diastolic dysfunction.
  • Maximum P-wave duration (Pmax) and P-wave dispersion (Pd) were significantly higher in HCV patients (99.3 ms vs. 82.4 ms and 44.1 ms vs. 25.3 ms, respectively).
  • No significant differences were found in left ventricle systolic parameters, including ejection fraction.

Conclusions:

  • Hepatitis C virus infection is associated with impaired left ventricular diastolic function.
  • HCV may contribute to the development of cardiac arrhythmias.
Abstract

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