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Taste masked microspheres of ofloxacin: formulation and evaluation of orodispersible tablets

Karan Malik1, Gurpreet Arora, Inderbir Singh

  • 1School of Pharmaceutical Sciences, Chitkara University, Solan-174103, Himachal Pradesh, India.

Scientia Pharmaceutica
|September 3, 2011
PubMed

Insights

This study developed taste-masked ofloxacin microspheres using Eudragit and locust bean gum orodispersible tablets to improve patient compliance by overcoming the antibiotic's unpleasant taste.

Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Materials Science

Background:

  • Ofloxacin is an antibiotic effective against bacterial infections.
  • Poor patient compliance is linked to ofloxacin's bitter taste.
  • Taste masking is crucial for improving oral drug administration.

Purpose of the Study:

  • To develop taste-masked ofloxacin microspheres using Eudragit E100.
  • To formulate these microspheres into orodispersible tablets using locust bean gum.
  • To evaluate the efficacy of taste masking and tablet properties.

Main Methods:

  • Ofloxacin microspheres were prepared via solvent evaporation technique using Eudragit E100.
  • Differential Scanning Calorimetry (DSC) was used to assess drug-polymer interactions.
  • Orodispersible tablets were formulated incorporating locust bean gum as a natural superdisintegrant.

Main Results:

  • Entrapment efficiency of microspheres ranged from 69.54% to 86.52%.
  • Optimal drug/polymer ratios (1:4, 1:5) demonstrated good flow and taste masking.
  • Orodispersible tablets exhibited rapid disintegration (10-22 seconds) and high drug release (>97% in 2 hours).

Conclusions:

  • Eudragit E100 effectively masks the bitter taste of ofloxacin.
  • Locust bean gum serves as a suitable natural superdisintegrant for orodispersible tablets.
  • This formulation approach enhances patient compliance for ofloxacin therapy.
Keywords:
Locust bean gumMicrospheresOfloxacinOrodispersible tabletsSolvent evaporation

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