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Thrombotic microangiopathy as a complication of recurrent pancreatitis

P Malleshappa1, A P Chaudhari, M Aghariya

  • 1Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India.

Indian Journal of Nephrology
|September 3, 2011
PubMed

Insights

Thrombotic microangiopathy is rarely caused by acute pancreatitis. This case report details a patient who recovered fully from thrombotic microangiopathy after developing acute pancreatitis, highlighting a rare clinical presentation.

Area of Science:

  • Internal Medicine
  • Hematology
  • Gastroenterology

Background:

  • Thrombotic microangiopathy, including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), is a rare complication of acute pancreatitis.
  • While TTP/HUS can cause pancreatitis, pancreatitis-induced TTP/HUS is exceptionally uncommon.

Observation:

  • A 40-year-old woman with idiopathic recurrent pancreatitis presented with acute pancreatitis complicated by thrombotic microangiopathy.
  • This represents the first reported case of TTP/HUS associated with pancreatitis in India.

Findings:

  • The patient experienced acute pancreatitis leading to thrombotic microangiopathy.
  • The condition was successfully treated with plasma exchange therapy.

Implications:

  • This case underscores the rare but potential causal link between acute pancreatitis and thrombotic microangiopathy.
  • Early recognition and appropriate treatment, such as plasma exchange, are crucial for favorable outcomes in these complex cases.
Keywords:
Pancreatitisplasma exchange therapythrombotic microangiopathy

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