Related Experiment Video
Updated: May 29, 2026

A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
Published on: March 15, 2016
Organophosphate acetylcholine esterase inhibitor poisoning from a home-made shampoo
Yair Sadaka1, Arnon Broides, Raffi Lev Tzion
1Department of Pediatric Emergency, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Insights
Organophosphate poisoning in children can occur from homemade shampoos. Promptly rinsing skin and scalp is crucial if poisoning is suspected from unclear sources.
Area of Science:
- Toxicology
- Pediatric Intensive Care
Background:
- Organophosphate acetylcholine esterase inhibitor (AChEI) poisoning is a significant pediatric health concern.
- AChEI poisoning can lead to severe neurological and physiological effects in children.
Observation:
- Two children presented with AChEI poisoning after using a homemade shampoo for head lice treatment.
- The source of poisoning was initially unclear, delaying diagnosis in one child.
Findings:
- Homemade shampoos can be an unusual source of organophosphate AChEI poisoning in children.
- Both affected children recovered fully without complications.
Implications:
- Clinicians should inquire about homemade shampoo use in cases of unexplained AChEI poisoning.
- Immediate and thorough rinsing of skin and scalp is recommended upon suspected exposure to prevent absorption.
Abstract:
Organophosphate acetylcholine esterase inhibitor poisoning is a major health problem in children. We report an unusual cause of organophosphate acetylcholine esterase inhibitor poisoning. Two children were admitted to the pediatric intensive care unit due to organophosphate acetylcholine esterase inhibitor poisoning after exposure from a home-made shampoo that was used for the treatment of head lice. Owing to no obvious source of poisoning, the diagnosis of organophosphate acetylcholine esterase inhibitor poisoning in one of these patients was delayed. Both patients had an uneventful recovery. Organophosphate acetylcholine esterase inhibitor poisoning from home-made shampoo is possible. In cases where the mode of poisoning is unclear, direct questioning about the use of home-made shampoo is warranted, in these cases the skin and particularly the scalp should be rinsed thoroughly as soon as possible.
More Related Videos
05:20Determination of 45 Pesticides in Avocado Varieties by the QuEChERS Method and Gas Chromatography-Tandem Mass Spectrometry
Published on: December 8, 2023
04:17Analysis of Organochlorine Pesticides in a Soil Sample by a Modified QuEChERS Approach Using Ammonium Formate
Published on: January 20, 2023
Related Concept Videos
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Indirect-Acting Cholinergic Agonists: Pharmacokinetics
Reversible agents containing quaternary amines, such as neostigmine and edrophonium, are not easily absorbed orally because they are...
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...