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Updated: May 29, 2026

Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

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Published on: November 3, 2009

Toxoplasmosis: a global threat.

João M Furtado¹, Justine R Smith, Rubens Belfort

¹Casey Eye Institute, Division of International Ophthalmology, Oregon Health & Science University, Portland, Oregon.

Journal of Global Infectious Diseases

|September 3, 2011

Summary

This summary is machine-generated.

Toxoplasmosis, a global disease caused by Toxoplasma gondii, frequently affects the retina and central nervous system, particularly in immunocompromised individuals. Reducing transmission through education and new drugs is crucial for public health.

Keywords:

Congenital toxoplasmosis Ocular toxoplasmosis Toxoplasmic encephalitis

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Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient

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Published on: November 3, 2009

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity

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Published on: March 12, 2015

Area of Science:

Ophthalmology
Infectious Diseases
Parasitology

Background:

Toxoplasmosis is a worldwide disease caused by the protozoan Toxoplasma gondii.
Ocular involvement, specifically the retina, is a common manifestation.
The disease poses significant risks to immunocompromised individuals and in cases of congenital infection due to potential central nervous system (CNS) involvement.

Purpose of the Study:

To summarize the global impact and common manifestations of toxoplasmosis.
To highlight the increased severity in specific populations.
To discuss potential strategies for reducing disease transmission and burden.

Main Methods:

Literature review of toxoplasmosis epidemiology and clinical impact.
Analysis of disease prevalence and risk factors.
Discussion of current and potential prevention strategies.

Main Results:

Toxoplasmosis is globally prevalent, with the retina being a common site of infection.
Immunocompromised individuals and congenital cases face severe CNS complications.
Toxoplasma gondii seroprevalence remains high, notably in South America.

Conclusions:

Simple prophylactic measures are effective but underutilized, leading to persistent high seroprevalence.
Educational campaigns are essential for reducing transmission.
Development of novel drugs for primary infection prevention is needed to alleviate the disease burden.