Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 29, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Adjusting wheal size measures to correct atopy misclassification.

Hongmei Zhang1, Wilfried Karmaus, Jianjun Gan

  • 1Department of Epidemiology and Biostatistics, The University of South Carolina, Columbia, SC, USA. hzhang@sc.edu

International Journal of General Medicine
|September 3, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Semiparametric Bayesian variable selection for gene-environment interactions.

Statistics in medicine·2019
Same author

Biallelic loss-of-function mutations in JAM2 cause primary familial brain calcification.

Brain : a journal of neurology·2019
Same author

Effect of Particle Size on Microstructure and Element Diffusion at the Interface of Tungsten Carbide/High Strength Steel Composites.

Materials (Basel, Switzerland)·2019
Same author

Association of asthma and smoking with lung function impairment in adolescence and early adulthood: the Isle of Wight Birth Cohort Study.

The European respiratory journal·2019
Same author

Epigenome wide comparison of DNA methylation profile between paired umbilical cord blood and neonatal blood on Guthrie cards.

Epigenetics·2019
Same author

Changes in DNA methylation from pre- to post-adolescence are associated with pubertal exposures.

Clinical epigenetics·2019
Same journal

Awareness and Understanding of Ionizing and Non-Ionizing Radiation Modalities Among Patients in Saudi Arabia.

International journal of general medicine·2026
Same journal

Development and Validation of an Interpretable Machine Learning Model Based on Peripheral Blood Biomarkers for Esophageal Cancer Risk Prediction.

International journal of general medicine·2026
Same journal

Screening for Abdominal Aortic Aneurysm in Elderly Male Patients with Coronary Artery Disease During Standard Transthoracic Echocardiography.

International journal of general medicine·2026
Same journal

Machine Learning-Based Prediction Model for Type 2 Diabetic Peripheral Neuropathy: Role of Bilateral Brachial-Ankle Pulse Wave Velocity and Anthropometric Indicators.

International journal of general medicine·2026
Same journal

Clinical Characteristics and Independent Risk Factors of Primary Gastrointestinal Lymphoma Complicated with Gastrointestinal Complications.

International journal of general medicine·2026
Same journal

Comparative Analysis of Clinical Characteristics and Antimicrobial Resistance of IA-BSI Caused by <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>.

International journal of general medicine·2026
See all related articles

This study introduces a new Bayesian method to adjust skin prick test (SPT) wheal sizes, aiming to reduce gender bias in allergy diagnosis. Revised, gender-specific cutoff points are proposed for more accurate atopy assessment.

Area of Science:

  • Allergy and Immunology
  • Statistical Modeling
  • Dermatology

Background:

  • Skin prick testing (SPT) is crucial for diagnosing allergies and predicting disease severity.
  • Current positive test cutoffs (3 mm) may not accurately reflect allergen-specific reactions due to factors like skin reactivity.
  • Gender disparities in atopy classification based on standard SPT cutoffs have been observed.

Purpose of the Study:

  • To develop a statistical method for isolating allergen-specific wheal sizes in SPT.
  • To propose gender-specific cutoff points for atopy to improve diagnostic accuracy.
  • To address and reduce gender-based misclassifications in allergy testing.

Main Methods:

  • A Bayesian approach was used to adjust observed wheal sizes, accounting for histamine and other confounding factors.
Keywords:
Bayesian methodSPTatopyjoint modelingmisclassification

More Related Videos

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

Related Experiment Videos

Last Updated: May 29, 2026

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
08:02

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation

Published on: March 24, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

  • The developed method was applied to a study population on the Isle of Wight, UK.
  • Statistical tests, including t-tests and proportion tests, were used to evaluate the approach.

    • Main Results:

    • Analysis of four common aeroallergens (house dust mite, grass pollen, dog dander, alternaria) revealed potential gender-based misclassifications.
    • The proposed adjustment method indicated that males might be more frequently misclassified as atopic compared to females.
    • Allergen-specific and gender-specific cutoff values for SPT were proposed based on the adjusted wheal sizes.

    Conclusions:

    • Implementing gender-specific cutoff values can help mitigate discrepancies in atopy diagnosis.
    • An alternative approach involves adjusting allergen concentrations in SPT solutions while maintaining current cutoff values.
    • These strategies aim to enhance the precision and fairness of allergy diagnosis through SPT.