Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 29, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Sustained negative BOLD response in human fMRI finger tapping task.

Yadong Liu1, Hui Shen, Zongtan Zhou

  • 1College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan, People's Republic of China.

Plos One
|September 3, 2011
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MsGCN: a multi-stream graph convolutional network for multiband PLV graph fusion in EEG-based biometric identification.

Frontiers in computational neuroscience·2026
Same author

Reinforcement learning in linear embedding space unlocks generalizable control across soft robot configurations.

Nature communications·2026
Same author

Dual controllability de-differentiation of functional brain networks in major depressive disorder: Insights from large-scale neuroimaging and transcriptomic integration.

Journal of affective disorders·2026
Same author

Functional connectivity-based classification and subtyping of major depression for precision mental health: An ensemble graph neural network approach.

PLOS digital health·2026
Same author

Multi-Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Transfer learning from 2D natural images to 4D fMRI brain images via geometric mapping.

Medical image analysis·2026
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

This study reveals that sustained negative BOLD responses (sNBR) during finger tapping are more widespread than previously thought. Findings suggest neuronal activity suppression, not "blood steal," is the likely cause of sNBR.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)

Background:

  • The sustained negative blood oxygen level-dependent (sNBR) response is a less understood phenomenon compared to the positive BOLD response (PBR).
  • Previous research has not fully characterized the extent and nature of sNBR during motor tasks.

Purpose of the Study:

  • To investigate the sustained negative BOLD response (sNBR) using fMRI during a finger tapping task.
  • To compare the spatial structure, area, amplitude, and dynamics of sNBR with its positive BOLD response (PBR) counterpart.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to measure brain activity during a finger tapping task.
  • Analysis focused on the sustained negative BOLD response (sNBR) and its comparison with the positive BOLD response (PBR).
  • Cortical regions were categorized into frontal, somatosensory, and occipital groups for detailed analysis.

More Related Videos

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

Related Experiment Videos

Last Updated: May 29, 2026

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis
10:33

Correlating Behavioral Responses to fMRI Signals from Human Prefrontal Cortex: Examining Cognitive Processes Using Task Analysis

Published on: June 20, 2012

Deep Brain Stimulation with Simultaneous fMRI in Rodents
11:09

Deep Brain Stimulation with Simultaneous fMRI in Rodents

Published on: February 15, 2014

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
08:55

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

Published on: February 8, 2018

Main Results:

  • The sNBR during finger tapping was observed to be more extensive than previously reported, involving frontal, somatosensory, and occipital regions.
  • The somatosensory group showed the most activated voxels but the smallest sNBR amplitude.
  • sNBR exhibited longer onset and peak times but a shorter falling edge time compared to PBR, with distinct spatial separation suggesting independent vascular origins.

Conclusions:

  • The findings indicate that the extensive sNBR observed in finger tapping tasks is more likely attributed to neuronal activity suppression rather than the
  • blood steal
  • phenomenon.
  • The distinct spatial and temporal characteristics of sNBR and PBR suggest they should be investigated separately due to potentially different underlying physiological mechanisms and vascular supplies.