Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...

Aortic Regurgitation I: Introduction

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

Aortic Regurgitation III: Medical Management

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Outcomes of microaxial flow pump use in acute-on-chronic heart failure.

JHLT open·2026

Same author

Unravelling chain confinement and dynamics of weakly entangled polymers in one component nanocomposites.

Soft matter·2025

Same author

Influence of implant strategy on the transition from temporary left ventricular assist device to durable mechanical circulatory support.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2024

Same author

A novel type of neighbour perception elicits reproductive plasticity in an annual plant with a mixed mating system.

Plant biology (Stuttgart, Germany)·2024

Same author

Towards optimal use of antithrombotic therapy of people with cancer at the end of life: A research protocol for the development and implementation of the SERENITY shared decision support tool.

Thrombosis research·2023

Same author

Excimer laser electrode extraction in the presence of a leadless pacemaker: a case report.

Clinical research in cardiology : official journal of the German Cardiac Society·2023

Search research articles

Related Experiment Video

Updated: May 29, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

[German Registry for Acute Aortic Dissection Type A (GERAADA): initial results].

L O Conzelmann¹, T Krüger, I Hoffmann

¹Klinik und Poliklinik für Herz-, Thorax- und Gefässchirurgie, Universitätsmedizin der Johannes Gutenberg-Universität, Langenbeckstr. 1, 55131, Mainz, Deutschland.

|September 3, 2011

Summary

The German registry for acute aortic dissection type A (GERAADA) identified risk factors for patient outcomes. This analysis aims to improve perioperative management and surgical treatment for acute aortic dissection type A.

Related Experiment Videos

Last Updated: May 29, 2026

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Novel and Innovative Hybrid Technique for Type A Aortic Dissection

Published on: March 28, 2025

Area of Science:

Cardiovascular Surgery
Thoracic Surgery
Vascular Surgery

Context:

The German registry for acute aortic dissection type A (GERAADA) was established in July 2006 by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS).
GERAADA is a web-based database designed to collect data on patients undergoing surgery for aortic dissection type A (AADA).
The registry aims to improve perioperative management and surgical treatment by analyzing AADA patient data and identifying risk factors.

Purpose:

To analyze data from the GERAADA registry to identify risk factors influencing patient outcomes in AADA.
To optimize perioperative management and surgical treatment strategies for AADA patients.
To provide clinically relevant insights and potentially establish therapeutic recommendations and guidelines for AADA treatment.

Summary:

The GERAADA registry enrolled 2137 AADA patients from 50 cardiac surgery centers between July 2006 and June 2009.
Thirty-day mortality was 17%. Antegrade cerebral perfusion is recommended for arch interventions exceeding 30 minutes of circulatory arrest.
Surgical strategy (ascending aorta vs. ascending aorta with arch repair) did not significantly impact 30-day mortality. Surgery is feasible and offers better outcomes than non-surgical treatment in elderly AADA patients, including octogenarians.

Impact:

GERAADA analyses provide crucial insights into AADA patient care, aiming to reduce morbidity and mortality.
The findings support the necessity of open surgical intervention for AADA.
The registry's data contributes to developing consensus guidelines for standard medical treatment and improving patient outcomes.