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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Clinical features of colonic diverticular disease
N Symeonidis1, K Psarras, M Lalountas
12nd Propedeutical Department of Surgery, Medical School, Hippokratio General Hospital, Aristotle University of Thessaloniki, 49 Konstantinoupoleos str, PC, 54642 Thessaloniki, Greece. niksym@hotmail.com
Colonic diverticular disease affects many, causing symptoms like bleeding or inflammation. Complications and diagnostic challenges highlight ongoing research needs in diverticulitis.
Area of Science:
- Gastroenterology
- Colorectal Surgery
Background:
- Colonic diverticular disease is highly prevalent in developed nations.
- While many with diverticulosis are asymptomatic, one-third experience symptomatic disease, including hemorrhage or inflammation.
- Diverticulitis presents as uncomplicated or complicated, with potential for abscess, perforation, fistula, obstruction, or stricture.
Purpose of the Study:
- To explore the complexities and diagnostic challenges of colonic diverticular disease.
- To address controversies surrounding recurrent diverticulitis and management in specific patient groups.
Main Methods:
- Literature review and clinical data analysis were implicitly used to synthesize information on diverticular disease.
- Comparative analysis of clinical presentations of diverticulitis, irritable bowel syndrome, and segmental colitis associated with diverticulosis.
Main Results:
- Symptomatic uncomplicated diverticular disease can mimic irritable bowel syndrome.
- Acute diverticulitis diagnosis can be challenging, often confused with segmental colitis associated with diverticulosis.
- Significant clinical overlap exists, indicating unresolved questions in the physiopathology of these conditions.
Conclusions:
- The physiopathology of colonic diverticular disease and related conditions requires further investigation.
- Diagnostic clarity is needed, especially given the overlap with other gastrointestinal disorders.
- Management strategies for recurrent or complicated diverticulitis, particularly in special populations, remain areas of debate.
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