Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Type I Diabetes I: Introduction

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...

What is the Immune System?

What is the Immune System?

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis.

Cellular & molecular immunology·2015

Same author

Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2015

Same author

Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'.

Gastroenterology·2015

Same author

Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.

Journal of hepatology·2015

Same author

The Significance of Autoantibody Changes Over Time in Primary Biliary Cirrhosis.

American journal of clinical pathology·2015

Same author

Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'.

Gut·2015

Search research articles

Related Experiment Video

Updated: May 29, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

Cutting-edge issues in organ-specific autoimmunity.

M Eric Gershwin¹, Yehuda Shoenfeld

¹Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis School of Medicine, Davis, USA. megershwin@ucdavis.edu

Clinical Reviews in Allergy & Immunology

|September 3, 2011

Summary

This review explores autoimmune diseases, moving beyond traditional organ-specific and non-specific classifications. It highlights emerging concepts in conditions like autoimmune pancreatitis and ANCA-associated vasculitis, emphasizing shared themes in their causes and mechanisms.

More Related Videos

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Related Experiment Videos

Last Updated: May 29, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection

Published on: August 20, 2007

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Area of Science:

Immunology
Pathology
Endocrinology

Background:

Traditional classification of autoimmune diseases separates them into organ-specific and organ-non-specific categories.
Classic examples include rheumatoid arthritis and systemic lupus erythematosus (SLE) as systemic diseases, and autoimmune thyroiditis and autoimmune gastritis as organ-specific diseases.
Expanding understanding of immune tolerance loss has broadened the spectrum of known autoimmune conditions.

Framework:

This issue reviews recent advancements in understanding autoimmune pancreatitis, primary sclerosing cholangitis, Goodpasture's syndrome, myofasciitis, type I diabetes, polymyositis, autoimmune thyroid disease, IgA nephropathy, autoimmune uveitis, and ANCA-associated vasculitis.
The traditional dichotomy between organ-specific and systemic autoimmunity is increasingly blurred.
Focus is placed on common etiological factors and effector mechanisms across diverse autoimmune diseases.

Implementation:

Discusses recent concepts in autoimmune pancreatitis and primary sclerosing cholangitis.
Covers autoimmune thyroid disease, type I diabetes, and IgA nephropathy.
Addresses Goodpasture's syndrome, myofasciitis, polymyositis, autoimmune uveitis, and ANCA-associated vasculitis.

Implications:

Provides a cutting-edge overview of current research in autoimmune diseases.
Highlights common themes in etiology and effector mechanisms, facilitating a more unified understanding.
Suggests a shift towards integrated approaches in diagnosing and treating autoimmune conditions.