Related Experiment Video
Updated: May 29, 2026

Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing (ChIP-seq)
Published on: April 19, 2013
Gene × environment interactions in type 2 diabetes
1Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Skåne University Hospital Malmö, 205 02 Malmö, Sweden. paul.franks@med.lu.se
Abstract:
People vary genetically in their susceptibility to the effects of environmental risk factors for many diseases. Genetic variation also underlies the extent to which people respond appropriately to clinical therapies. Defining the basis to the interactions between the genome and the environment may help elucidate the biologic basis to diseases such as type 2 diabetes, as well as help target preventive therapies and treatments. This review examines 1) some of the most current evidence on gene × environment interactions in relation to type 2 diabetes; 2) outlines how the availability of information on gene × environment interactions might help improve the prevention and treatment of type 2 diabetes; and 3) discusses existing and emerging strategies that might enhance our ability to detect and exploit gene × environment interactions in complex disease traits.
Related Concept Videos
Type II Diabetes I: Introduction
Gene-Environment Interactions
Type I Diabetes II: Pathophysiology
Type II Diabetes II: Pathophysiology
Diabetes Mellitus: Type 2 and Gestational
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...

