Related Experiment Video
Updated: May 29, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Weight loss and severe jaundice in a patient with hyperthyroidism
M Breidert1, S Offensperger, H E Blum
1Department of Internal Medicine I, District Hospital Clinic Altmühltal, Kösching, Germany. Matthias.Breidert@klinikkoesching.de
Background:
Thyrotoxicosis may significantly alter hepatic function and is associated with autoimmune disorders of the liver.
Case Report:
We report the case of a thyrotoxic patient with Graves' disease and histologically established cholestatic hepatitis. Medical treatment of hyperthyroidism normalized liver function tests.
Conclusions:
In patients with elevated liver function parameters and jaundice of unknown origin, thyroid function should generally be tested. Moreover, medical treatment of hyperthyroidism with thyrostatics may cause severe hepatitis whereas untreated hyperthyroid patients are at risk of developing chronic liver failure.
Related Concept Videos
Hyperthyroidism I: Introduction
Jaundice
Hyperthyroidism II: Pathophysiology
Graves' Disease I: Introduction
Hypothyroidism II: Pathophysiology
Graves Disease II: Pathophysiology
