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Updated: May 29, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Glomerular filtration rate in early diabetes: ongoing discussions of causes and mechanisms
1The Water and Salt Research Center, University of Aarhus, Aarhus C, Denmark. sfri@ana.au.dk
Abstract:
Glomerular hyperfiltration (>140 ml/min per 1.73 m2 body surface area) is found in early diabetes and is associated with a poor prognosis with respect to the development of diabetic kidney disease. This review addresses recent investigations and discussions of the following hypotheses behind diabetic hyperfiltration: Increased proximal tubular volume reabsorption results in a pressure drop in Bowman's capsule which increases glomerular filtration rate (GFR). Proximal tubular hyperreabsorption induces an increase in GFR mediated by tubuloglomerular feedback. Dietary NaCl restriction results in a paradoxically increased GFR and increased urine volume in diabetic animals.
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