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Updated: May 29, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Dual-functional electrospun poly(2-hydroxyethyl methacrylate).

Bo Zhang1, Reza Lalani, Fang Cheng

  • 1Department of Chemical and Biomolecular Engineering, University of Akron, Akron, Ohio 44325, USA.

Journal of Biomedical Materials Research. Part A
|September 3, 2011
PubMed
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This summary is machine-generated.

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Electrospun poly(2-hydroxyethyl methacrylate) (pHEMA) fibers offer tunable diameters and high water absorption. These dual-functional materials resist protein adsorption while allowing biomolecule immobilization for tissue engineering and wound dressings.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Poly(2-hydroxyethyl methacrylate) (pHEMA) is a biocompatible polymer widely used in biomedical applications.
  • Porous scaffolds with high surface-area-to-volume ratios are crucial for tissue engineering, mimicking natural extracellular matrices.
  • Systematic control over pHEMA fiber diameter and morphology, along with exploration of their applications, remains underexplored.

Purpose of the Study:

  • To synthesize and electrospin poly(2-hydroxyethyl methacrylate) (pHEMA) into fibrous scaffolds with controlled fiber diameters.
  • To investigate the physical properties, protein adsorption resistance, and biomolecule immobilization capacity of these pHEMA fibrous scaffolds.
  • To evaluate the potential of functionalized pHEMA scaffolds in promoting cell behavior for tissue engineering applications.

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Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study

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Last Updated: May 29, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Electrospinning Fibrous Polymer Scaffolds for Tissue Engineering and Cell Culture
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Tri-layered Electrospinning to Mimic Native Arterial Architecture using Polycaprolactone, Elastin, and Collagen: A Preliminary Study
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Main Methods:

  • Poly(2-hydroxyethyl methacrylate) (pHEMA) was synthesized and processed into fibrous scaffolds via electrospinning.
  • Fiber diameters were controlled by adjusting polymer solution concentration and electrospinning flow rate.
  • Post-electrospinning thermal treatment was applied to enhance membrane integrity in aqueous environments.

Main Results:

  • Electrospun pHEMA fibers with diameters ranging from 270 nm to 3.6 μm were successfully fabricated.
  • Thermal treatment significantly improved the water integrity of the electrospun membranes.
  • pHEMA microfibrous membranes showed high water absorption (up to 280% w/w) and resisted nonspecific protein adsorption.
  • Activated hydroxyl groups enabled protein immobilization, achieving a bovine serum albumin (BSA) binding capacity of 120 mg BSA/g membrane.
  • Collagen I-functionalized scaffolds enhanced fibroblast adhesion, spreading, and proliferation.

Conclusions:

  • Electrospun pHEMA fibers exhibit dual functionality: resistance to nonspecific protein adsorption and capacity for biomolecule conjugation.
  • The high water absorption and tunable properties of these fibers make them suitable for various biomedical applications.
  • Potential applications include advanced wound dressings, tissue engineering scaffolds, and affinity membranes.