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Related Experiment Videos

Multihormonal pituitary adenomas.

P U Heitz

    Hormone Research
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Most pituitary tumors are mixed, producing multiple hormones. This study found that 56 out of 66 autopsy-detected pituitary tumors contained hormone-producing cells, with 45 producing two or more hormones.

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    Area of Science:

    • Endocrinology
    • Oncology
    • Pathology

    Background:

    • Pituitary tumors are common neoplasms.
    • Previous studies suggested heterogeneity in pituitary tumor hormone production.

    Purpose of the Study:

    • To investigate the prevalence of hormone production in pituitary tumors.
    • To determine the extent of multi-hormone production in these tumors.

    Main Methods:

    • Autopsy-detected pituitary tumors (n=66) were analyzed.
    • Immunocytochemistry was used to detect specific pituitary hormones.

    Main Results:

    • Hormone-producing cells were identified in 56 (85%) of the tumors.
    • 45 (68%) of the tumors contained cells producing two or more hormones.

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  • Detected hormones included corticotropin, beta-lipotrophin, growth hormone, prolactin, thyrotropin, and gonadotropins.

    • Conclusions:

    • The majority of pituitary tumors are mixed, co-producing multiple hormones.
    • This supports the hypothesis that pituitary tumors arise from dysregulation at the hypothalamic and/or pituitary level.