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Published on: June 2, 2014
Sublingual piroxicam in migraine without aura
K Ravishankar1, Himanshu Tayade, Rahul Mandlik
1'The Headache and Migraine Clinic', Jaslok Hospital and Research Centre, 15, G. Deshmukh Marg, Mumbai 400026, India.
The Journal of the Association of Physicians of India
|September 6, 2011
Summary
Sublingual piroxicam provides rapid pain relief for migraine attacks. This study found it significantly reduced pain and associated symptoms with excellent tolerability compared to placebo.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine without aura is a common neurological condition causing significant pain.
- Effective acute management of migraine attacks is crucial for patient quality of life.
Purpose of the Study:
- To compare the analgesic efficacy of sublingual piroxicam versus placebo for acute migraine without aura.
Main Methods:
- A randomized, double-blind, placebo-controlled study.
- 60 patients (18-50 years) with migraine without aura received either sublingual piroxicam (40 mg) or placebo.
- Pain intensity and associated symptoms were evaluated post-administration.
Main Results:
- Sublingual piroxicam significantly reduced pain intensity within 15 minutes (P < 0.05).
- Associated migraine symptoms resolved significantly with piroxicam.
- 83.3% of patients reported excellent to good response with piroxicam versus 10% with placebo.
- No adverse side effects were reported.
Conclusions:
- Sublingual piroxicam is an effective and well-tolerated treatment for acute migraine without aura.
- It offers rapid and significant pain relief.
- Piroxicam demonstrates superior efficacy compared to placebo in managing migraine attacks.
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