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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Lupus nephritis associated with CD20+ B-cell NHL
M R Gumber1, V B Kute, K R Goplani
1Department of Nephrology and Clinical Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases and Research Centre (IKDRC)- Dr H L Trivedi Institute of Transplantation Sciences (ITS), Civil Hospital Campus, Asarwa, Ahmedabad 380016, Gujarat, India.
The Journal of the Association of Physicians of India
|September 6, 2011
Summary
This case report details a rare instance of lymphoma-associated glomerulonephritis and lupus nephritis in a patient with Epstein-Barr virus infection. Successful treatment was achieved using the R-CHOP regimen.
Area of Science:
- Nephrology
- Oncology
- Immunology
Background:
- Malignancy-associated glomerulonephritis is an uncommon complication of non-Hodgkin lymphoma (NHL).
- Epstein-Barr virus (EBV) infection can trigger autoimmune conditions like systemic lupus erythematosus (SLE) and lymphomas such as diffuse large B-cell lymphoma (DLBCL).
Observation:
- A 45-year-old male presented with untreated NHL and lupus nephritis.
- Immunohistochemistry confirmed CD20+ DLBCL in a lymph node biopsy.
- Renal biopsy revealed lupus nephritis (class V + IV), and serology indicated EBV infection.
Findings:
- The patient exhibited a rare co-occurrence of SLE and DLBCL.
- Complete remission of both SLE and DLBCL was achieved following treatment with the R-CHOP regimen (rituximab, cyclophosphamide, vincristine, doxorubicin, prednisone).
Implications:
- This case highlights the complex interplay between NHL, EBV, SLE, and glomerulonephritis.
- The successful R-CHOP treatment demonstrates a viable therapeutic strategy for this rare clinical presentation.
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