Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

206
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
206
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

216
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
216
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

205
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
205
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

209
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
209
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

178
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
178
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

174
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
174

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Common Questions About Streptococcal Pharyngitis.

American family physician·2016
Same author

Intertrigo and secondary skin infections.

American family physician·2014
Same author

Physical activity guidelines for older adults.

American family physician·2010
See all related articles

Related Experiment Video

Updated: Jan 8, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

10.4K

The geriatric assessment.

Bassem Elsawy1, Kim E Higgins

  • 1Methodist Charlton Medical Center, Dallas, Texas 75237, USA. bassemelsawy@mhd.com

American Family Physician
|September 6, 2011
PubMed
Summary
This summary is machine-generated.

The geriatric assessment is a comprehensive evaluation of older adults, covering physical health, cognition, and social factors. It helps diagnose conditions, plan care, and improve quality of life.

More Related Videos

Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

13.4K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.7K

Related Experiment Videos

Last Updated: Jan 8, 2026

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

Published on: September 30, 2020

10.4K
Oral Health Assessment by Lay Personnel for Older Adults
08:47

Oral Health Assessment by Lay Personnel for Older Adults

Published on: February 2, 2020

13.4K
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.7K

Area of Science:

  • Geriatrics
  • Internal Medicine
  • Public Health

Background:

  • Older adults often present complex health needs.
  • Standard medical evaluations may not fully capture geriatric challenges.
  • A multidimensional approach is crucial for effective elder care.

Purpose of the Study:

  • To define the scope and components of a geriatric assessment.
  • To highlight its advantages over standard medical evaluations.
  • To emphasize its role in comprehensive elder care planning.

Main Methods:

  • Multidimensional and multidisciplinary evaluation.
  • Assessment of functional ability, physical health, cognition, mental health, and socioenvironmental factors.
  • Utilizes validated tools for specific domains like ADLs, continence, and cognition.

Main Results:

  • Geriatric assessment identifies medical, functional, and psychosocial issues comprehensively.
  • It aids in diagnosis, treatment planning, care coordination, and long-term care evaluation.
  • Incorporates nonmedical domains and emphasizes functional capacity and quality of life.

Conclusions:

  • Geriatric assessment provides a more complete picture of an older adult's health.
  • It is essential for optimizing care and placement decisions for the elderly.
  • A "rolling" assessment approach can manage multiple concerns over time.